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vr 1238 emcv emc strain atcc  (ATCC)


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    ATCC vr 1238 emcv emc strain atcc
    Figure 4. HIF activation exerts broad antiviral activity in neuron-like cells (A and B) Virus titer of vesicular stomatitis virus (VSV) and <t>encephalomyocarditis</t> <t>virus</t> <t>(EMCV)</t> in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 19 h with EMCV (MOI 0.1) or VSV (MOI 0.001). n = 3 biological replicates. (C) SARS-CoV-2 N2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 48 h with SARS-CoV-2 (MOI 1). Data were normalized against 18S rRNA. n = 5 biological replicates. (D) Influenza A virus M2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 24 h with influenza A virus (MOI 0.1). Data were normalized against 18S rRNA. n = 5 biological replicates. (E) Measles virus titer in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 36 h with Measles virus (MOI 0.1). n = 6 biological replicates. Data are representative of at least three independent experiments. The data are shown as means ± SD. Individual values are represented by dots. For (A), Mann- Whitney was applied to identify statistical significance. For (B)–(E), the statistical analyses were performed by Student’s t test, two-tailed, parametric distribution to identify statistical significance. ns, not significant. Illustrations of viruses were generated with BioRender.
    Vr 1238 Emcv Emc Strain Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 433 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/vr+1238+emcv+emc+strain+atcc/Vesicular+stomatitis+virus/pm38363679-238-191-195
    Average 94 stars, based on 433 article reviews
    vr 1238 emcv emc strain atcc - by Bioz Stars, 2026-09
    94/100 stars

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    1) Product Images from "The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation."

    Article Title: The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.

    Journal: Cell reports

    doi: 10.1016/j.celrep.2024.113792

    Figure 4. HIF activation exerts broad antiviral activity in neuron-like cells (A and B) Virus titer of vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV) in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 19 h with EMCV (MOI 0.1) or VSV (MOI 0.001). n = 3 biological replicates. (C) SARS-CoV-2 N2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 48 h with SARS-CoV-2 (MOI 1). Data were normalized against 18S rRNA. n = 5 biological replicates. (D) Influenza A virus M2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 24 h with influenza A virus (MOI 0.1). Data were normalized against 18S rRNA. n = 5 biological replicates. (E) Measles virus titer in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 36 h with Measles virus (MOI 0.1). n = 6 biological replicates. Data are representative of at least three independent experiments. The data are shown as means ± SD. Individual values are represented by dots. For (A), Mann- Whitney was applied to identify statistical significance. For (B)–(E), the statistical analyses were performed by Student’s t test, two-tailed, parametric distribution to identify statistical significance. ns, not significant. Illustrations of viruses were generated with BioRender.
    Figure Legend Snippet: Figure 4. HIF activation exerts broad antiviral activity in neuron-like cells (A and B) Virus titer of vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV) in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 19 h with EMCV (MOI 0.1) or VSV (MOI 0.001). n = 3 biological replicates. (C) SARS-CoV-2 N2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 48 h with SARS-CoV-2 (MOI 1). Data were normalized against 18S rRNA. n = 5 biological replicates. (D) Influenza A virus M2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 24 h with influenza A virus (MOI 0.1). Data were normalized against 18S rRNA. n = 5 biological replicates. (E) Measles virus titer in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 36 h with Measles virus (MOI 0.1). n = 6 biological replicates. Data are representative of at least three independent experiments. The data are shown as means ± SD. Individual values are represented by dots. For (A), Mann- Whitney was applied to identify statistical significance. For (B)–(E), the statistical analyses were performed by Student’s t test, two-tailed, parametric distribution to identify statistical significance. ns, not significant. Illustrations of viruses were generated with BioRender.

    Techniques Used: Activation Assay, Activity Assay, Virus, Infection, Quantitative RT-PCR, MANN-WHITNEY, Two Tailed Test, Generated

    Related Articles

    Virus:

    Article Title: The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies HIF-1alpha (D2U3T) Cell Signaling #14179S; RRID:AB_2622225 THOC1 Sigma-Aldrich #HPA019687-25UL; RRID:AB_1857980 Vinculin Sigma-Aldrich #V9131-0.2ML; RRID:AB_477629 LC3B Cell Signaling #2775; RRID:AB_915950 ATG5 (D5F5U) Cell Signaling #12994; RRID:AB_2630393 VHL Cell Signaling #68547; RRID:AB_2716279 BNIP3 Cell Signaling #44060; RRID:AB_2799259 STAT1 Cell Signaling #9172; RRID:AB_2198300 pSTAT1 Cell Signaling #7694S; RRID:AB_10950970 IFNAR2 Abcam #ab193410 TBK1 Cell Signaling #38066; RRID:AB_2827657 pTBK1 Cell Signaling #5483; RRID:AB_10693472 V5 Abcam #ab27671; RRID:AB_471093 IRF3 Cell Signaling #4302; RRID:AB_1904036 pIRF3 Cell Signaling #37829; RRID:AB_2799121 STING Cell Signaling #13647; RRID:AB_2732796 pSTING Cell Signaling #50907; RRID:AB_2827656 peroxidase-conjugated F(ab)2 donkey anti-mouse IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340774 peroxidase-conjugated F(ab)2 donkey anti-rabbit IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340590 LC3 Nordic Biosite #PM036; RRID:AB_2274121 P62 Progen #GP62-C; RRID:AB_2687531 ICP5/VP5 Abcam Ab6508 b-Tubulin Cell Signaling #2146; RRID:AB_2210545 Alexa 488 Thermo Fischer #A-21206; RRID:AB_2535792 Alexa A568 Thermo Fischer #A-11075; RRID:AB_2534119 DAPI Santa Cruz #sc-3598 goat anti-mouse IgG1 biotin SouthernBiotech #1071-08; RRID: AB_2794427 Bacterial and virus strains HSV-1 (KOS) strain ATCC # VR-1493 HSV-2 (333) strain Kristina Eriksson Iversen et al.6 Clinical isolates HSV-1 2762 Kristina Eriksson Iversen et al.6 HSV-2 B4327UR Kristina Eriksson Iversen et al.6 VSV (Indiana) strain ATCC #VR-1238 EMCV (EMC) strain ATCC #VR-129B Influenza virus A (H1N1), PR8 strain ATCC #VR-1469 Measles virus (Edmonston) strain ATCC #VR-24 SARS-CoV-2 (MZ314997/B.1.1.7 variant) Arvind Patel, University of Glasgow SARS-CoV-2 B1.1.7 Chemicals, peptides, and recombinant proteins CoCl2 Sigma-Aldrich #14726-62-6 Diethyl succinate Sigma-Aldrich #123-25-1 Dimethyl sulfoxide (DMSO) Sigma-Aldrich #67-68-5 Vadadustat MedChemExpress #HY-101277 (Continued on next page) Cell Reports 43, 113792, February 27, 2024 17 .. REAGENT or RESOURCE SOURCE IDENTIFIER MK-8617 MedChemExpress #HY-101023 Dimethyloxallyl Glycine MedChemExpress #HY-15893 ML228 Tocris #4565 Poly(I:C) LMW InvivoGen #tlrl-picw 2-Deoxy-D-glucose Sigma-Aldrich #D8375 Alt-R S.p. cas9 Nuclease V3, 500 mg Integrated DNA Technologies #1081059 Critical commercial assays Hypoxyprobe-1TMPlus Kit Hydroxyprobe HP2-200Kit High Pure RNA Isolation kit Roche #11828665001 NE-PER Nuclear and Cytoplasmic Extraction Reagent Kit Thermo Fisher Scientific #78833 Brilliant III Ultra-Fast SYBR Green QRT-PCR Master Mix kit Agilent Technologi #600886 RNA-to-Ct-1-Step kit Applied BioSYSTEMS #4392653 TaqPathTM qPCR Master Mix Applied Biosystems #A16245 CXCL10 ELISA kit Bio-techne #DY466 KAPA mRNA Hyper Prep Kit Roche N/A SMARTer Stranded Total RNA-Seq Kit v2- Pico Input Takara N/A SMARTer Stranded Total RNA Sample Prep Kit- HI Mammalian Takara N/A Deposited data RNA-seq This paper European Nucleotide Archive.

    Variant Assay:

    Article Title: The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies HIF-1alpha (D2U3T) Cell Signaling #14179S; RRID:AB_2622225 THOC1 Sigma-Aldrich #HPA019687-25UL; RRID:AB_1857980 Vinculin Sigma-Aldrich #V9131-0.2ML; RRID:AB_477629 LC3B Cell Signaling #2775; RRID:AB_915950 ATG5 (D5F5U) Cell Signaling #12994; RRID:AB_2630393 VHL Cell Signaling #68547; RRID:AB_2716279 BNIP3 Cell Signaling #44060; RRID:AB_2799259 STAT1 Cell Signaling #9172; RRID:AB_2198300 pSTAT1 Cell Signaling #7694S; RRID:AB_10950970 IFNAR2 Abcam #ab193410 TBK1 Cell Signaling #38066; RRID:AB_2827657 pTBK1 Cell Signaling #5483; RRID:AB_10693472 V5 Abcam #ab27671; RRID:AB_471093 IRF3 Cell Signaling #4302; RRID:AB_1904036 pIRF3 Cell Signaling #37829; RRID:AB_2799121 STING Cell Signaling #13647; RRID:AB_2732796 pSTING Cell Signaling #50907; RRID:AB_2827656 peroxidase-conjugated F(ab)2 donkey anti-mouse IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340774 peroxidase-conjugated F(ab)2 donkey anti-rabbit IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340590 LC3 Nordic Biosite #PM036; RRID:AB_2274121 P62 Progen #GP62-C; RRID:AB_2687531 ICP5/VP5 Abcam Ab6508 b-Tubulin Cell Signaling #2146; RRID:AB_2210545 Alexa 488 Thermo Fischer #A-21206; RRID:AB_2535792 Alexa A568 Thermo Fischer #A-11075; RRID:AB_2534119 DAPI Santa Cruz #sc-3598 goat anti-mouse IgG1 biotin SouthernBiotech #1071-08; RRID: AB_2794427 Bacterial and virus strains HSV-1 (KOS) strain ATCC # VR-1493 HSV-2 (333) strain Kristina Eriksson Iversen et al.6 Clinical isolates HSV-1 2762 Kristina Eriksson Iversen et al.6 HSV-2 B4327UR Kristina Eriksson Iversen et al.6 VSV (Indiana) strain ATCC #VR-1238 EMCV (EMC) strain ATCC #VR-129B Influenza virus A (H1N1), PR8 strain ATCC #VR-1469 Measles virus (Edmonston) strain ATCC #VR-24 SARS-CoV-2 (MZ314997/B.1.1.7 variant) Arvind Patel, University of Glasgow SARS-CoV-2 B1.1.7 Chemicals, peptides, and recombinant proteins CoCl2 Sigma-Aldrich #14726-62-6 Diethyl succinate Sigma-Aldrich #123-25-1 Dimethyl sulfoxide (DMSO) Sigma-Aldrich #67-68-5 Vadadustat MedChemExpress #HY-101277 (Continued on next page) Cell Reports 43, 113792, February 27, 2024 17 .. REAGENT or RESOURCE SOURCE IDENTIFIER MK-8617 MedChemExpress #HY-101023 Dimethyloxallyl Glycine MedChemExpress #HY-15893 ML228 Tocris #4565 Poly(I:C) LMW InvivoGen #tlrl-picw 2-Deoxy-D-glucose Sigma-Aldrich #D8375 Alt-R S.p. cas9 Nuclease V3, 500 mg Integrated DNA Technologies #1081059 Critical commercial assays Hypoxyprobe-1TMPlus Kit Hydroxyprobe HP2-200Kit High Pure RNA Isolation kit Roche #11828665001 NE-PER Nuclear and Cytoplasmic Extraction Reagent Kit Thermo Fisher Scientific #78833 Brilliant III Ultra-Fast SYBR Green QRT-PCR Master Mix kit Agilent Technologi #600886 RNA-to-Ct-1-Step kit Applied BioSYSTEMS #4392653 TaqPathTM qPCR Master Mix Applied Biosystems #A16245 CXCL10 ELISA kit Bio-techne #DY466 KAPA mRNA Hyper Prep Kit Roche N/A SMARTer Stranded Total RNA-Seq Kit v2- Pico Input Takara N/A SMARTer Stranded Total RNA Sample Prep Kit- HI Mammalian Takara N/A Deposited data RNA-seq This paper European Nucleotide Archive.

    Recombinant:

    Article Title: The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies HIF-1alpha (D2U3T) Cell Signaling #14179S; RRID:AB_2622225 THOC1 Sigma-Aldrich #HPA019687-25UL; RRID:AB_1857980 Vinculin Sigma-Aldrich #V9131-0.2ML; RRID:AB_477629 LC3B Cell Signaling #2775; RRID:AB_915950 ATG5 (D5F5U) Cell Signaling #12994; RRID:AB_2630393 VHL Cell Signaling #68547; RRID:AB_2716279 BNIP3 Cell Signaling #44060; RRID:AB_2799259 STAT1 Cell Signaling #9172; RRID:AB_2198300 pSTAT1 Cell Signaling #7694S; RRID:AB_10950970 IFNAR2 Abcam #ab193410 TBK1 Cell Signaling #38066; RRID:AB_2827657 pTBK1 Cell Signaling #5483; RRID:AB_10693472 V5 Abcam #ab27671; RRID:AB_471093 IRF3 Cell Signaling #4302; RRID:AB_1904036 pIRF3 Cell Signaling #37829; RRID:AB_2799121 STING Cell Signaling #13647; RRID:AB_2732796 pSTING Cell Signaling #50907; RRID:AB_2827656 peroxidase-conjugated F(ab)2 donkey anti-mouse IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340774 peroxidase-conjugated F(ab)2 donkey anti-rabbit IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340590 LC3 Nordic Biosite #PM036; RRID:AB_2274121 P62 Progen #GP62-C; RRID:AB_2687531 ICP5/VP5 Abcam Ab6508 b-Tubulin Cell Signaling #2146; RRID:AB_2210545 Alexa 488 Thermo Fischer #A-21206; RRID:AB_2535792 Alexa A568 Thermo Fischer #A-11075; RRID:AB_2534119 DAPI Santa Cruz #sc-3598 goat anti-mouse IgG1 biotin SouthernBiotech #1071-08; RRID: AB_2794427 Bacterial and virus strains HSV-1 (KOS) strain ATCC # VR-1493 HSV-2 (333) strain Kristina Eriksson Iversen et al.6 Clinical isolates HSV-1 2762 Kristina Eriksson Iversen et al.6 HSV-2 B4327UR Kristina Eriksson Iversen et al.6 VSV (Indiana) strain ATCC #VR-1238 EMCV (EMC) strain ATCC #VR-129B Influenza virus A (H1N1), PR8 strain ATCC #VR-1469 Measles virus (Edmonston) strain ATCC #VR-24 SARS-CoV-2 (MZ314997/B.1.1.7 variant) Arvind Patel, University of Glasgow SARS-CoV-2 B1.1.7 Chemicals, peptides, and recombinant proteins CoCl2 Sigma-Aldrich #14726-62-6 Diethyl succinate Sigma-Aldrich #123-25-1 Dimethyl sulfoxide (DMSO) Sigma-Aldrich #67-68-5 Vadadustat MedChemExpress #HY-101277 (Continued on next page) Cell Reports 43, 113792, February 27, 2024 17 .. REAGENT or RESOURCE SOURCE IDENTIFIER MK-8617 MedChemExpress #HY-101023 Dimethyloxallyl Glycine MedChemExpress #HY-15893 ML228 Tocris #4565 Poly(I:C) LMW InvivoGen #tlrl-picw 2-Deoxy-D-glucose Sigma-Aldrich #D8375 Alt-R S.p. cas9 Nuclease V3, 500 mg Integrated DNA Technologies #1081059 Critical commercial assays Hypoxyprobe-1TMPlus Kit Hydroxyprobe HP2-200Kit High Pure RNA Isolation kit Roche #11828665001 NE-PER Nuclear and Cytoplasmic Extraction Reagent Kit Thermo Fisher Scientific #78833 Brilliant III Ultra-Fast SYBR Green QRT-PCR Master Mix kit Agilent Technologi #600886 RNA-to-Ct-1-Step kit Applied BioSYSTEMS #4392653 TaqPathTM qPCR Master Mix Applied Biosystems #A16245 CXCL10 ELISA kit Bio-techne #DY466 KAPA mRNA Hyper Prep Kit Roche N/A SMARTer Stranded Total RNA-Seq Kit v2- Pico Input Takara N/A SMARTer Stranded Total RNA Sample Prep Kit- HI Mammalian Takara N/A Deposited data RNA-seq This paper European Nucleotide Archive.



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    vr 1238 emcv emc strain atcc  (ATCC)
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    ATCC vr 1238 emcv emc strain atcc
    Figure 4. HIF activation exerts broad antiviral activity in neuron-like cells (A and B) Virus titer of vesicular stomatitis virus (VSV) and <t>encephalomyocarditis</t> <t>virus</t> <t>(EMCV)</t> in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 19 h with EMCV (MOI 0.1) or VSV (MOI 0.001). n = 3 biological replicates. (C) SARS-CoV-2 N2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 48 h with SARS-CoV-2 (MOI 1). Data were normalized against 18S rRNA. n = 5 biological replicates. (D) Influenza A virus M2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 24 h with influenza A virus (MOI 0.1). Data were normalized against 18S rRNA. n = 5 biological replicates. (E) Measles virus titer in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 36 h with Measles virus (MOI 0.1). n = 6 biological replicates. Data are representative of at least three independent experiments. The data are shown as means ± SD. Individual values are represented by dots. For (A), Mann- Whitney was applied to identify statistical significance. For (B)–(E), the statistical analyses were performed by Student’s t test, two-tailed, parametric distribution to identify statistical significance. ns, not significant. Illustrations of viruses were generated with BioRender.
    Vr 1238 Emcv Emc Strain Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/vr+1238+emcv+emc+strain+atcc/Vesicular+stomatitis+virus/pm38363679-238-191-195
    Average 94 stars, based on 1 article reviews
    vr 1238 emcv emc strain atcc - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier

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    Figure 4. HIF activation exerts broad antiviral activity in neuron-like cells (A and B) Virus titer of vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV) in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 19 h with EMCV (MOI 0.1) or VSV (MOI 0.001). n = 3 biological replicates. (C) SARS-CoV-2 N2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 48 h with SARS-CoV-2 (MOI 1). Data were normalized against 18S rRNA. n = 5 biological replicates. (D) Influenza A virus M2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 24 h with influenza A virus (MOI 0.1). Data were normalized against 18S rRNA. n = 5 biological replicates. (E) Measles virus titer in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 36 h with Measles virus (MOI 0.1). n = 6 biological replicates. Data are representative of at least three independent experiments. The data are shown as means ± SD. Individual values are represented by dots. For (A), Mann- Whitney was applied to identify statistical significance. For (B)–(E), the statistical analyses were performed by Student’s t test, two-tailed, parametric distribution to identify statistical significance. ns, not significant. Illustrations of viruses were generated with BioRender.

    Journal: Cell reports

    Article Title: The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.

    doi: 10.1016/j.celrep.2024.113792

    Figure Lengend Snippet: Figure 4. HIF activation exerts broad antiviral activity in neuron-like cells (A and B) Virus titer of vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV) in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 19 h with EMCV (MOI 0.1) or VSV (MOI 0.001). n = 3 biological replicates. (C) SARS-CoV-2 N2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 48 h with SARS-CoV-2 (MOI 1). Data were normalized against 18S rRNA. n = 5 biological replicates. (D) Influenza A virus M2 RNA levels evaluated by RT-qPCR in total RNA from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 24 h with influenza A virus (MOI 0.1). Data were normalized against 18S rRNA. n = 5 biological replicates. (E) Measles virus titer in culture supernatants from SH-Sy5y cells treated with ML228 (0.5 mM) and infected for 36 h with Measles virus (MOI 0.1). n = 6 biological replicates. Data are representative of at least three independent experiments. The data are shown as means ± SD. Individual values are represented by dots. For (A), Mann- Whitney was applied to identify statistical significance. For (B)–(E), the statistical analyses were performed by Student’s t test, two-tailed, parametric distribution to identify statistical significance. ns, not significant. Illustrations of viruses were generated with BioRender.

    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies HIF-1alpha (D2U3T) Cell Signaling #14179S; RRID:AB_2622225 THOC1 Sigma-Aldrich #HPA019687-25UL; RRID:AB_1857980 Vinculin Sigma-Aldrich #V9131-0.2ML; RRID:AB_477629 LC3B Cell Signaling #2775; RRID:AB_915950 ATG5 (D5F5U) Cell Signaling #12994; RRID:AB_2630393 VHL Cell Signaling #68547; RRID:AB_2716279 BNIP3 Cell Signaling #44060; RRID:AB_2799259 STAT1 Cell Signaling #9172; RRID:AB_2198300 pSTAT1 Cell Signaling #7694S; RRID:AB_10950970 IFNAR2 Abcam #ab193410 TBK1 Cell Signaling #38066; RRID:AB_2827657 pTBK1 Cell Signaling #5483; RRID:AB_10693472 V5 Abcam #ab27671; RRID:AB_471093 IRF3 Cell Signaling #4302; RRID:AB_1904036 pIRF3 Cell Signaling #37829; RRID:AB_2799121 STING Cell Signaling #13647; RRID:AB_2732796 pSTING Cell Signaling #50907; RRID:AB_2827656 peroxidase-conjugated F(ab)2 donkey anti-mouse IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340774 peroxidase-conjugated F(ab)2 donkey anti-rabbit IgG (H + L) Jackson ImmunoResearch #PRID: AB_2340590 LC3 Nordic Biosite #PM036; RRID:AB_2274121 P62 Progen #GP62-C; RRID:AB_2687531 ICP5/VP5 Abcam Ab6508 b-Tubulin Cell Signaling #2146; RRID:AB_2210545 Alexa 488 Thermo Fischer #A-21206; RRID:AB_2535792 Alexa A568 Thermo Fischer #A-11075; RRID:AB_2534119 DAPI Santa Cruz #sc-3598 goat anti-mouse IgG1 biotin SouthernBiotech #1071-08; RRID: AB_2794427 Bacterial and virus strains HSV-1 (KOS) strain ATCC # VR-1493 HSV-2 (333) strain Kristina Eriksson Iversen et al.6 Clinical isolates HSV-1 2762 Kristina Eriksson Iversen et al.6 HSV-2 B4327UR Kristina Eriksson Iversen et al.6 VSV (Indiana) strain ATCC #VR-1238 EMCV (EMC) strain ATCC #VR-129B Influenza virus A (H1N1), PR8 strain ATCC #VR-1469 Measles virus (Edmonston) strain ATCC #VR-24 SARS-CoV-2 (MZ314997/B.1.1.7 variant) Arvind Patel, University of Glasgow SARS-CoV-2 B1.1.7 Chemicals, peptides, and recombinant proteins CoCl2 Sigma-Aldrich #14726-62-6 Diethyl succinate Sigma-Aldrich #123-25-1 Dimethyl sulfoxide (DMSO) Sigma-Aldrich #67-68-5 Vadadustat MedChemExpress #HY-101277 (Continued on next page) Cell Reports 43, 113792, February 27, 2024 17

    Techniques: Activation Assay, Activity Assay, Virus, Infection, Quantitative RT-PCR, MANN-WHITNEY, Two Tailed Test, Generated